Liver disease is common in dogs and liver tumors are one of many potential causes of canine liver disease. Liver tumors in dogs occur in many different forms. Canine hepatic tumors may be primary tumors, derived from the liver itself, or they may be metastatic, derived from another body tissue and spread to the liver from that tissue. Liver tumors may be malignant (cancerous) or benign (non-cancerous). Canine liver tumors can also take on different shapes, including:

• massive - a solitary localized lesion within the liver
• diffuse - affecting the entire area of the liver in an even distribution pattern
• nodular - numerous discreet lesions located within the liver

Types of Canine Liver Tumors

The most common types of liver tumors seen in dogs are:

• hepatocellular carcinoma (malignant)
• hepatocellular adenoma (usually benign)
• hepatoblastoma (rare)
• biliary carcinoma (malignant)
• biliary adenoma (benign)
• neuroendocrine (carcinoid) tumors (rare)
• hemangiosarcoma (a malignancy of blood vessels, a common secondary tumor)
• fibrosarcoma (a malignancy of fibrous tissue)
• osteosarcoma (a bone malignancy)
• leiomyosarcoma (a smooth muscle malignancy)

Primary Versus Metastatic Liver Cancer in Dogs

Liver tumors can be primary or metastatic. Malignant liver cancer is more likely to be metastatic than primary and the most common tissues of origin are:

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